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. 2017 Feb 15;42(9):1860–1870. doi: 10.1038/npp.2017.14

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Copyright © 2017 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Heroin-paired context reexposure elevated GluN2B–ERK1/2 signaling in the dDG. (a) Western blot analysis of AMPAR subunit GluA1 and GluA2 membrane/total protein level in the dDG after 30 min context-induced reinstatement testing. No difference was found between control and renewal group for GluA1 and GluA2 subunits using unpaired t-test, respectively; n=7 per group. (b) NMDAR subunit GluN1, GluN2A, and GluN2B membrane/total protein level in the dDG after 30 min context-induced reinstatement testing. *P<0.05 vs control group using unpaired t-test; n=7 per group. (c) GluN2B activation in the dDG after context-induced reinstatement testing. Left, western blot analysis of phosphorylation of GluN2B at Y1472 and S1480 in the dDG immediately after 30 min context-induced reinstatement testing. *P<0.05 vs control group using unpaired t-test. Right, correlation of context-induced reinstatement behavior with pY1472 GluN2B activation in the renewal group; n=7 per group. (d) ERK1/2 and pERK1/2 protein level in the dDG after 30 min context-induced reinstatement testing. Left, western blot analysis of phosphorylation of ERK1/2 and pERK1/2 in the dDG immediately after context-induced reinstatement testing. *P<0.05 vs control group using unpaired t-test. Right, correlation of context-induced reinstatement behavior with PERK1/2 activation in the renewal group; n=7 per group. Data are depicted as mean±SEM.