Figure 1.
Experimental timeline. This flowchart provides a summary of the experimental timeline. From top to bottom, the progression of 18FDG microPET scans and treatment with morphine, methadone (METH), and buprenorphine (BUP) is delineated by postnatal day (PND). Scan 1 refers to the baseline (pretreatment) imaging time point. Scan 2 refers to images obtained after spontaneous withdrawal (control), subchronic METH replacement, and subchronic BUP replacement. Study group drug dosing, treatment duration, and sample size are noted in the figure.