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. Author manuscript; available in PMC: 2018 Mar 1.
Published in final edited form as: Cancer J. 2017 Mar-Apr;23(2):131–137. doi: 10.1097/PPO.0000000000000251

Table 2.

DC Subsets in Human

Dendritic cell subset Alternative names Key surface markers Associated gene signature Functions
Conventional DC type 1-cDC1 BDCA3+ DC/CD141+ DC HLADR+CD11c+CD141+Clec9a+XCR1+CADM1+ IRF8, batf3, Bc16, Flt3, CLNK Cross presentation of dead cell associated antigens to CD8 T cells, Type III IFN production under TLR-3 triggering
Conventional DC type 2-CDc2 BDCA1 DC/CD1c+ DC HLADR+CD11c+CD1c+CD172+ IRF4, Notch2, Rbpj, Klf4 Activation of CD4 T cells, IL-12 production
plasmacytoid DC - pDC BDCA2+ DC HLADR+CD11c-CD123+CD303+CD304+CD45RA+ IRF8, Bcl11a, Spi-B, E2-2, Runx1 Major producer of the type I IFN, Anti viral immunity
Langerhans cells-LC HLADR+CD11c+CD1a+CD207+ EPCAM, ABCC4 and BMPR1A Major component of skin immunity,
inflammatory dendritic cells-inf-DC MoDCs HLADR+CD11c+CD11b+CD206+CD209 +/− MAFB, FCGR2B, TPI1 Major source of Nitric oxide and tumor necrosis factor during infection and inflammation