Table 1. Univariate and multivariate analyses of prognostic factors in HCC (cohort 2, n=323).
| Variable |
TTR |
OS |
||
|---|---|---|---|---|
| HR (95% CI) | P | HR (95% CI) | P | |
| Univariate analysis | ||||
| Age, year (⩽50 versus >50) | 0.977 (0.726–1.315) | 0.879 | 1.207 (0.889–1.640) | 0.228 |
| Sex (female versus male) | 1.863 (1.143–3.036) | 0.013 | 1.757 (1.049–2.942) | 0.032 |
| HBsAg (negative versus positive) | 0.978 (0.664–1.442) | 0.912 | 1.002 (0.670–1.498) | 0.993 |
| AFP, ng/ml (⩽20 versus >20) | 1.155 (0.835–1.597) | 0.385 | 1.548 (1.083–2.211) | 0.016 |
| GGT, U/l (⩽54 versus >54) | 1.329 (0.978–1.805) | 0.069 | 1.737 (1.253–2.409) | 0.001 |
| Liver cirrhosis (no versus yes) | 1.160 (0.712–1.889) | 0.552 | 1.362 (0.801–2.315) | 0.254 |
| Tumor size, cm (⩽5 versus >5) | 1.817 (1.346–2.452) | 0.000 | 2.482 (1.806–3.412) | 0.000 |
| Tumor number (single versus multiple) | 1.362 (0.907–2.044) | 0.136 | 1.517 (1.025–2.243) | 0.037 |
| Microvascular invasion (no versus yes) | 1.915 (1.420–2.583) | 0.000 | 2.479 (1.815–3.388) | 0.000 |
| Tumor encapsulation (complete versus none) | 1.228 (0.860–1.754) | 0.259 | 1.638 (1.160–2.314) | 0.005 |
| Tumor differentiationa (I+II versus III+IV) | 1.679 (1.246–2.263) | 0.001 | 1.715 (1.260–2.336) | 0.001 |
| TNM stage (I versus II–III) | 1.226 (0.912–1.650) | 0.178 | 1.563 (1.149–2.125) | 0.004 |
| 5-hmC (low versus high) | 0.709 (0.520–0.967) | 0.030 | 0.707 (0.512–0.974) | 0.034 |
| Multivariate analysis | ||||
| Sex (female versus male) | 1.777 (1.089–2.901) | 0.021 | NA | NA |
| AFP, ng/ml (⩽20 versus >20) | NA | NA | NA | NA |
| GGT, U/l (⩽54 versus >54) | NA | NA | 1.458 (1.037–2.049) | 0.030 |
| Tumor size, cm (⩽5 versus >5) | 1.722 (1.263–2.350) | 0.001 | 2.123 (1.512–2.979) | 0.000 |
| Tumor number (single versus multiple) | NA | NA | NA | NA |
| Microvascular invasion (no versus yes) | 1.563 (1.143–2.137) | 0.005 | 2.137 (1.543–2.959) | 0.001 |
| Tumor encapsulation (complete versus none) | 1.647 (1.211–2.239) | 0.001 | 1.663 (1.207–2.291) | 0.002 |
| Tumor differentiationa (I+II versus III+IV) | NA | NA | 1.737 (1.225–2.463) | 0.002 |
| TNM stage (I versus II–III)a | NA | NA | NA | NA |
| 5-hmC (low versus high) | 0.634 (0.463– 0.867) | 0.004 | 0.654 (0.472–0.906) | 0.011 |
Abbreviations: 5-hmC, 5-hydroxymethylcytosine; AFP, alpha-fetoprotein; CI, confidential interval; GGT, gamma glutamyl transferase; HBsAg, hepatitis B surface antigen; HR, hazard ratio; NA, not adopted; TNM, tumor-node-metastasis
a
Edmondson grade
Analyses were conducted using univariate analysis or multivariate Cox proportional hazards regression