Table 2. Univariate and multivariate analysis for overall survival in NPC patients (Cox proportional hazards regression model).

Variables	Univariate analysis			Multivariate analysis
	HR	CI	P-value	HR	CI	P-value
Age: ⩽45 versus >45	0.213	0.096–0.472	0.001	0.206	0.093–0.458	0.001
Gender: male versus female	1.428	0.585–3.486	0.434			NS
T stage: T1–3 versus T4	1.066	0.338–3.367	0.913			NS
N stage: N0–1 versus N2–3	0.782	0.356–1.718	0.541			NS
M stage: M0 versus M1	0.176	0.049–0.629	0.007	0.156	0.054–0.451	0.001
Clinical stage: I–II versus III–IV	0.527	0.179–1.553	0.247	0.529	0.252–1.113	0.093
NEDD8 expression: low versus high	0.315	0.148–0.668	0.003	0.303	0.144–0.640	0.002

Abbreviations: HR, hazard ratio; CI, confidence interval.

P-values were calculated by log-rank test. Bold values indicate statistically significant values.