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. 2017 Jun 1;8(6):e2843. doi: 10.1038/cddis.2017.235

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Effect of IDF-11774 on energy metabolism. (a) Western blot analysis of the expression levels of proteins involved in AMPK activation in the presence or absence of IDF-11774. (b) Model depicting the mode of action of IDF-11774: IDF-11774 suppresses HIF-1α accumulation, thereby inhibiting glucose-dependent energy metabolism and mitochondrial respiration in cancer cells. HIF-1α accumulation was reduced by the enhanced degradation of HIF-1α consequent to increased local oxygen concentrations and the translational attenuation of HIF-1α by mTOR inactivation