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. 2017 Jun 1;8(6):e2843. doi: 10.1038/cddis.2017.235

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Antitumor efficacy of IDF-11774 in HCT116 xenograft models. Graphic depictions of tumor size in xenograft model mice in the presence or absence of (a) IDF-11774 (per oral (p.o.), 10, 30, or 60 mg/kg, once a day (q.d.)), (b) IDF-11774 and sunitinib (p.o., 30 mg/kg each, q.d.), (c) IDF-11774 (intranvenously (i.v.), 2/wk; 30 mg/kg, q.d.) and sunitinib (p.o., 30 mg/kg, q.d.), or (d) IDF-11774 (p.o., 60 mg/kg, q.d.) and sorafenib or lapatinib (p.o., 30 mg/kg each, q.d.). Data are presented as the means and standard deviations of the results from five independent experiments; ***P<0.001, compared with vehicle control