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. 2017 Jun 8;8(6):e2864. doi: 10.1038/cddis.2017.242

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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PDT-induced autophagy promotes the cholesterol efflux via ABCA1. (a) ATG5 expression was detected by western blotting. (b) The effect of ATG5 siRNA on the intracellular lipid burden was measured using Dil ox-LDL and DAPI staining (scale bar, 50 μm). (c) The effect of ATG5 siRNA on the co-localization between LC3 and Bodipy 2 h following the different treatments, as detected by LSCM (scale bar, 10 μm). (d) Quantitative detection of cholesterol efflux using a fluorometric assay at 6 h post-PDT. (e) The expression levels of the ATP-binding cassette transporters ABCA1 and ABCG1 at various time points after PDT (n=3; *P<0.05, **P<0.01 versus control group, ^###P<0.001 versus PDT group)