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. 2017 Jun 1;8(6):e2850. doi: 10.1038/cddis.2017.243

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Overexpression of miR-195 prevents 2VO-induced activation of the N-APP/DR6/caspase pathway. (a) miR-195 levels in the hippocampi and cortices of 2VO rats with or without lenti-pre-miR-195 treatment. (b and c) Lenti-pre-miR-195 prevented the increase of N-APP and DR6 expression in the hippocampi and cortices of 2VO rats. Mean±S.E.M., n=6, *P<0.05 versus sham, ^#P<0.05 versus 2VO. (d and e) Lenti-pre-miR-195 inhibited the cleavage of caspase-6 and caspase-3 in the hippocampus and cortex of 2VO rats. The magnification was × 20