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. 2017 Jun 8;8(6):e2866. doi: 10.1038/cddis.2017.257

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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ARRDC4 mediates K63 ubiquitination of MDA5. (a) Immunoblot analysis of K63 polyubiquitination of the precipitated MDA5 in t-M_Ø, which were transfected and stimulated as indicated. (b and c) HEK293T cells were transfected with indicated plasmids and infected with EV71 for 12 h, followed by IP with anti-Flag antibody. Immunoblot analysis of ubiquitination of MDA5; Ub-K0, mutant ubiquitin with no lysine residues retained. Data are representative of three independent experiments with similar results