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. 2017 Jun 8;8(6):e2862. doi: 10.1038/cddis.2017.258

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Overexpression of CRNDE promotes cell proliferation, cell cycling, invasion and migration in CRC cells in vitro. (a) Overexpression of CRNDE induced significantly higher growth rates in CRC cells. (b) Overexpression of CRNDE increased the capacity to form colonies in CRC cells. (c) Overexpression of CRNDE induced a significant increase in cells at G2-phase relative to mock cells. (d and e) Invasion/migration assays using Matrigel Transwell and wound-healing assays for CRC cells. CRNDE overexpression promoted the invasion and migration of CRC cells. The experiments were performed in triplicate; the data are expressed as the mean±S.D. *P<0.05, **P<0.01 and *** P<0.001