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. 2017 Jun 8;8(6):e2862. doi: 10.1038/cddis.2017.258

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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CRNDE activates Ras/MAPK signaling pathways. mRNA expression profiles were detected in CRNDE knockdown DLD1 cells and control cells. (a) KEGG pathway analysis of the genes downregulated in CRNDE-depleted cells. (b) Hierarchical clustering analysis of Ras/MAPK signaling genes which were downregulated in the CRNDE-depleted DLD1 cells. (c) A subset of genes was detected by real-time RT-PCR. The experiments were performed in triplicate, and the data are expressed as the mean±S.D.