Figure 1.

(a) MMC growth inhibition. FA-derived AML cells SB1690CB and progeny cell line SBRes were grown with increasing MMC concentrations and without MMC, and counted when untreated cultures had undergone three population doublings. Cell cultures with an IC50 of 10 nM or less were considered MMC sensitive in the FA range. Dose response analysis of sensitive and resistant cells to camptothecin (b) and cisplatin (c). Statistical analysis: Two way-ANOVA and Bonferroni post-test, *P<0.05. **P<0.01, ***P<0.001. FANCD2-mutated FA-disrupted CB1665 cells, and BRCA2-competent K562 cells were used as controls