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. 2017 Jun 15;8(6):e2875. doi: 10.1038/cddis.2017.264

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Expression phenotype of acquired MMC resistance. (a) Heat map illustration of differential gene expression between MMC-resistant and MMC-sensitive cells with and without MMC treatment (2MMol). 3828 differentially expressed genes (group ANOVA P<0.05) were identified. Clustering of the data within the heat map delineated distinct groups of gene expression patterns differentiating the MMC-resistant and sensitive states as indicated (total of 510 genes). Corresponding lists are provided in Supplementary Tables. (b) Numerical Venn diagram illustration of transcriptomic analysis (left, P<0.01), proteomic (middle) and phosphoproteomic (right) analysis comparing sensitive and resistant cell lines with and without MMC split into up and downregulated transcripts/proteins/phosphopeptides. Corresponding lists are provided in Supplementary Material