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. 2017 Jun 22;8(6):e2893. doi: 10.1038/cddis.2017.266

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Copyright © 2017 The Author(s)

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Protection from acute liver failure following exercise involves MAP kinases and NF-κB signaling as well as downregulation of TLR4 protein expression. Liver tissue of unchallenged and GalN/LPS-challenged mice in the voluntary wheel running (VWR) and sedentary group (SED) were harvested after 5 h and levels of (a) phosphorylated and total JNK, (b) phosphorylated c-Jun, (c) total and phosphorylated NFκB p65, (d) A20 and (e) TLR4 were determined by immunoblotting (representative western blots are shown)