Table 3. Effects of voluntary wheel running on hepatic expression levels of cytokines, NFκB and pattern recognition receptors in TNF-induced liver injury.

	VWR			SED			Post-GaIN/LPS VWR versus SED
	Pre- GaIN/LPS	Post-GaIN/LPS	P	Pre- GaIN/LPS	Post-GaIN/LPS	P	P
TNF	1.1E−04 (±8.1E−05)	1.1E−03 (±5.4E−04)	<0.001	1.3E−04 (±3.5E−05)	1.8E−03 (±8.9E−04)	<0.001	<0.05
IL-6	8.2E−05 (±7.6E−05)	1.0E−03 (±2.9E−04)	<0.001	2.6E−04 (±2.3E−04)	2.5E−03 (±2.1E−03)	<0.01	<0.05
MCP-1	8.3E−05 (±4.0E−05)	1.7E−02 (±1.2E−02)	<0.01	1.5E−04 (±5.8E−05)	4.7E−02 (±3.2E−02)	<0.01	<0.05
NFκB	1.9E−03 (±7.8E−04)	1.2E−02 (±3.7E−03)	<0.01	2.9E−02 (±2.2E−03)	1.3E−02 (±3.9E−03)	<0.001	0.6
TLR4	4.6E−03 (±5.9E−03)	6.5E−04 (±3.6E−04)	0.05	1.1E−02 (±1.3E−02)	7.9E−04 (±4.2E−04)	<0.05	0.45
TLR9	2.5E−03 (±4.2E−03)	2.4E−04 (±1.8E−04)	0.13	5.4E−03 (±6.7E−03)	3.4E−04 (±2.9E−04)	<0.05	0.35
STING	5.2E−03 (±8.0E−03)	1.4E−03 (±4.1E−04)	0.2	8.0E−03 (±1.0E−02)	2.1E−03 (±7.2E−04)	0.09	<0.05

For TNF, IL-6 and MCP-1 n=9 mice were used in each group, for NFκB, TLR4, TLR9 and STING n=11 mice were used in each group.