Table 2. Multivariate analysis of disease-free survival and overall survival in 367 CRC patients.

Factors	N	DFS		OS
		HR (95% CI)	P-value	HR (95% CI)	P-value
Age, years		1.196 (0.792, 1.806)	0.395	1.366 (0.818, 2.283)	0.233
⩽60	182
>60	185
Sex		0.867 (0.589, 1.276)	0.469	0.999 (0.635, 1.571)	0.995
Male	207
Female	160
pN status		2.194 (1.419, 3.393)	<0.001	1.473 (0.950, 2.283)	<0.001
N0	171
N1–N3	196
Grade		1.439 (0.876, 2.362)	0.150	1.521 (0.831, 2.782)	0.174
Well	105
Low/moderate	262
Tumor location		0.795 (0.536, 1.177)	0.252	1.042 (0.658, 1.650)	0.862
Rectum	189
Colon	178
Chemotherapy		0.314 (0.156, 0.634)	0.001	0.148 (0.065, 0.340)	<0.001
No	133
Yes	234
AQP9 expression		0.680 (0.455, 1.108)	0.061	0.790 (0.492, 1.267)	0.327
Low	198
High	169

Abbreviations: CI, confidence interval; DFS, disease-free survival; HR, hazard ratio; OS, overall survival.