Table 2. Necroptosis in neurodegenerative diseases.

Diseases	Role of necroptosis	References
Alzheimer's disease	Nec-1 improved neurobehavior in Al-treated mice model and increased survival of Al-induced neural cell death.	47, 48
	Nec-1 alleviated cognitive impairment with reduction of Aβ and tau abnormalities in APP/PS1 mice model.
Parkinson disease	Nec-1 ameliorated 6-OHDA treated PC12 cells survival.	58
Amyotrophic lateral sclerosis	Nec-1, NSA and RIP3 knockdown improved neuron viability in ALS astrocyte hES-MNs coculture system.	45, 62
	Increased expression of RIP1, RIP3 and MLKL in OPTN−/− mice, post-mortem patient spinal cords.
	Mutantion of RIP1 and RIP3 in OPTN−/− mice increased neuron viability.
Huntington disease	Nec-1 increased ST14A 8plx celll survival.	44
	Nec-1 improved R6/2 mice behavior and delayed symptom onset.
Niemann-Pick disease	Nec-1 prolong cell viability in NPC1 fibroblasts and NPC1 iPS-derived neuron.	82
	Nec-1 delayed cerebellar Purkinje cell loss, significantly prolonged lifespan.
	Increased levels of RIP1, RIP3 and MLKL in NPC1−/− mice and post-mortem patient tissues.
Gaucher’s disease	level of RIP1, RIP3, and c-FlipS were markedly elevated in Gbaflox/flox; nestin-Cre mice.
	Lifespan significantly extended in RIP3−/− mice injected with CBE than widetype mice.	88