Table 2. Cox regression.

(A) Cox-regression analysis of time to progression. (B) Cox-regression analysis of overall survival.

Clinicopathological variables	Univariate analysis		Multivariate analysis
	Hazard ratio (95% CI)	p-value	Hazard ratio (95% CI)	p-value
(A) Cox-regression analysis of time to progression
Sex	2.679 (1.154–6.223)	0.022	2.861 (1.210–6.762)	0.017
Age	0.964 (0.941–0.988)	0.004	0.961 (0.937–0.985)	0.002
Tumor size	1.061 (1.008–1.115)	0.022	1.063 (1.008–1.121)	0.025
Tumor number	1.088 (0.701–1.689)	0.707
Cirrhosis status	0.909 (0.678–1.218)	0.522
Differentiation status	0.770 (0.541–1.097)	0.770
DAPK1 staining status	0.486 (0.299 = 0.790)	0.004	0.479 (0.291–0.791)	0.004
(B) Cox-regression analysis of overall survival
Sex	1.400 (0.721–2.722)	0.320
Age	0.969 (0.948–0.992)	0.007	0.976 (0.954–0.997)	0.027
Tumor size	1.077 (1.029–1.128)	0.001	1.077 (1.030–1.127)	0.001
Tumor number	1.021 (0.644–1.618)	0.931
Cirrhosis status	0.841 (0.636–1.113)	0.227
Differentiation status	0.675 (0.484–0.941)	0.021
DAPK1 staining status	0.597 (0.382–0.932)	0.023	0.604 (0.384–0.951)	0.030