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. Author manuscript; available in PMC: 2017 Jul 21.
Published in final edited form as: Genes Chromosomes Cancer. 2013 Oct 21;53(1):25–37. doi: 10.1002/gcc.22115

Figure 4.

Figure 4

(A) A metaphase spread from UPCI:SCC084 shows translocation of one copy of the ATR gene (green) from chromosome 3 marked by CEP3 labeled red to another chromosome, which (B) further analysis reveals is a derivative chromosome 11 (red) with amplified CCND1 (aqua). (C) A representative image of a chromosome spread from UPCI:SCC104 revealing an isodicentric chromosome 3 (CEP3 in red) with ATR copy number gain (green). (D) Image showing the ATR gene in an anaphase bridge in the UPCI:SCC104 cell line, which may have resulted from the isodicentric chromosome 3.