TABLE 1.

ATR and CHEK1 Copy Number Changes in 20 Oral Cancer Cell Lines UPCI:SCC003–182 and Two Ovarian Cancer Cell Lines, SKOV3 and OVCAR-3

Cell Line	11q13 Amp	ATM loss	ATR			ATR:CEP3 ratio	Idic 3q	CHEK1			CHEK1:CEP11 ratio
			% Cells with gain	% Cells with loss	% Cells with no change			% Cells with gain	% Cells with loss	% Cells with no change
Normal			–	–	100	1.0	–	–	–	100	1.0
UPCI:
SCC003	+	+	53	1	46	1.6	−	1	93	6	0.71
SCC029B	+	+	89	2	9	1.4	−	–	99	1	0.61
SCC032	+	+	57	–	43	1.3	−	1	99	–	0.67
SCC040	+	+	53	–	47	1.6	−	5	94	1	0.56
SCC066	−	−	2	3	95	1.0	−	1	1	98	1.01
SCC070	+	+	89	1	10	2.1	+	–	98	2	0.57
SCC077	+	+	85	1	14	2.2	+	2	31	67	0.67
SCC078	+	+	9	3	88	1.0	−	–	94	6	1.05
SCC084	+	+	7	–	93	1.0	−	2	98	–	0.52
SCC099	−	−	3	6	91	1.0	−	–	100	–	1.0
SCC103	+	+	8	1	91	1.1	−	2	94	4	0.74
SCC104	−	+	98	–	2	2.2	+	1	11	88	0.97
SCC105	−	+	2.5	0.5	97	1.1	−	12	32	56	0.85
SCC116	−	−	3	2	95	1.0	−	3	10	87	0.94
SCC122	−	+	1	9	90	1.0	−	1	82	17	0.71
SCC131	+	+	92.5	–	7.5	2.1	+	–	98	2	0.44
SCC136	+	+	78.5	–	21.5	1.3	−	–	96	4	0.53
SCC142	−	+	98.5	–	1.5	2.1	+	–	91	9	0.67
SCC172	+	+	3	5	92	1.1	−	5	90	5	0.71
SCC182	−	−	1	1	98	1.0	−	3	–	97	1.01
SKOV3	−	−	4	3	93	1.1	−	1	–	99	1.0
OVCAR-3	−	+	99	–	1	9	−	8	–	92	1.1