. Author manuscript; available in PMC: 2017 Oct 4.

Published in final edited form as: J Alzheimers Dis. 2016 Oct 4;54(3):1027–1037. doi: 10.3233/JAD-160014

Table 2.

Group comparisons

Subfield	HC (n= 57)	aMCI (n = 38)	AD (n = 67)	HC > aMCI		HC > AD		aMCI > AD

				t value	p	t value	p	t value	p
CA1	1323.31	1041.04	950.72	5.71	<0.001	8.74	<0.001	0.98	0.328
(in mm³)	(172.74)	(203.61)	(216.83)	5.71	<0.001	8.74	<0.001	0.98	0.328
DG	746.22	625.81	529.79	3.82	<0.001	8.34	<0.001	2.85	0.006
(in mm³)	(97.98)	(132.73)	(117.91)	3.82	<0.001	8.34	<0.001	2.85	0.006
SUB	334.12	277.22	266.80	3.52	0.001	4.67	<0.001	0.06	0.955
(in mm³)	(48.02)	(57.05)	(65.30)	3.52	0.001	4.67	<0.001	0.06	0.955
ERC^*	25.54	20.72	18.07	4.71	<0.001	7.90	<0.001	1.93	0.057
(in mm²)	(4.01)	(4.12)	(3.97)	4.71	<0.001	7.90	<0.001	1.93	0.057
BA35^*	19.71	16.31	14.20	3.26	0.002	5.43	<0.001	1.46	0.147
(in mm²)	(3.83)	(4.01)	(4.21)	3.26	0.002	5.43	<0.001	1.46	0.147
BA36^*	74.94	65.63	55.36	2.31	0.024	5.27	<0.001	2.61	0.011
(in mm²)	(13.78)	(14.62)	(14.15)	2.31	0.024	5.27	<0.001	2.61	0.011
WH	2403.66	1944.08	1747.31	5.29	<0.001	8.78	<0.001	1.50	0.138
(in mm³)	(282.44)	(358.51)	(382.50)	5.29	<0.001	8.78	<0.001	1.50	0.138

Data are presented as mean values of subfield volume measurements followed by standard deviations in parentheses. Group comparisons are presented t values and p values with p < 0.004 after Bonferroni correction. HC, healthy control; aMCI, amnestic mild cognitive impairment; AD, Alzheimer’s disease; CA1, Cornu Ammonis 1; DG, dentate gyrus; SUB, subiculum; ERC, entorhinal cortex; BA35, Brodman area 35; BA36, Brodman area 36; WH, whole hippocampus.

Volumes are normalized by the A-P extent of the segmentation.