Fig. 3.

Pathway, function, and regulatory analysis of age-related transcriptomic changes. Age-related gene expression changes were analyzed with Ingenuity Knowledge Base for differentially regulated pathways (a), functions (b), and regulators (c). A relevant selection of over-represented categories (Fisher’s exact test p < 0.05) is given in heatmap form with coloring according to the computed z score. Z scores are based on prior knowledge of known regulatory functions and direction of changes in the current dataset. Z scores >2 indicate significant activation with aging and <−2 indicate significant inhibition with aging. Abbreviations are detailed in Additional file 1: Table S8