Fig. 4.

Enrichment of age-related changes in cell-specific transcripts. a Cell-specific transcripts from previous reports (Zeisel et al. [30] and Zhang et al. [31]) were compared to each pairwise set of age-related changes. Fisher’s exact test p values are plotted for cell types with significant over-representations. b Using gene sets derived from Hickman et al. [32] for the sensome, classical priming, and alternative microglial priming, a significant over-representation of sensome genes, in particular, is evident. c Previously published gene sets indicative of M0, M1, and M2 microglial states [33] were also examined for over-representation of age-related genes