Table 4.
Odds ratios (ORs) and corresponding 95% confidence intervals (CI) for the association between body size change from childhood to adolescence and overall risk of breast cancer
| KARMA | LIBRO1 | Combined | |||||||
|---|---|---|---|---|---|---|---|---|---|
| Body size change | n | Age-adjusted OR (95% CI) |
Multivariable OR (95% CI)a |
n | Age-adjusted OR (95% CI) |
Multivariable OR (95% CI)a |
n | Age-adjusted OR (95% CI) |
Multivariable OR (95% CI)b |
| Remained small | 615 | 1.00 (Reference) | 1.00 (Reference) | 1320 | 1.00 (Reference) | 1.00 (Reference) | 1935 | 1.00 (Reference) | 1.00 (Reference) |
| Decrease | 181 | 0.92 (0.82–1.05) | 0.89 (0.73–1.07) | 382 | 0.92 (0.81–1.05) | 0.91 (0.79–1.04) | 563 | 0.92 (0.83–1.02) | 0.90 (0.81–1.00) |
| Remained medium | 626 | 0.93 (0.82–1.05) | 0.91 (0.80–1.03) | 1067 | 0.73 (0.67–0.80) | 0.73 (0.66–0.80) | 1693 | 0.79 (0.74–0.85) | 0.79 (0.73–0.85) |
| Increase | 784 | 1.06 (0.94–1.19) | 1.04 (0.92–1.17) | 1555 | 0.91 (0.83–0.99) | 0.91 (0.84–0.99) | 2339 | 0.95 (0.89–1.02) | 0.95 (0.89–1.02) |
| Remained large | 66 | 0.78 (0.59–1.03) | 0.75 (0.56–0.99) | 130 | 0.63 (0.51–0.77) | 0.63 (0.52–0.77) | 196 | 0.67 (0.57–0.79) | 0.67 (0.57–0.79) |
n number of breast cancer cases
aAdjusted for age, age at menarche, family history of breast cancer, number of children and ever use of hormone replacement therapy
bAdjusted for study, age, age at menarche, family history of breast cancer, number of children and ever use of hormone replacement therapy