Table 2.

Rates of BRCA1/2 mutation testing

Year of breast surgery	N	Outcomes of Kaplan-Meier analysis (%)			Kaplan-Meier estimates of BRCA1/2 testing rates*
		Censored before 12/31/13	Follow up to 12/31/13	BRCA1/2 testing	Median time to testing (Months after surgery)	By surgery date % (95% CI)†	By one year after surgery % (95% CI)†	By five years after surgery % (95% CI)†
2005
Women age 40 and under	914	63.0	10.9	26.0	Not reached	4.9 (3.7–6.5)	19.6 (17.0–22.5)	35.3 (31.1–39.9)
Women age 41–45	1375	63.6	15.9	20.5	Not reached	2.2 (1.5–3.1)	13.1 (11.4–15.2)	25.0 (22.1–28.2)
2006
Women age 40 and under	888	45.3	11.6	43.1	66.4	6.6 (5.2–8.5)	32.9 (29.9–36.3)	48.3 (44.5–52.3)
Women age 41–45	1323	54.7	17.6	27.7	Not reached	4.8 (3.7–6.1)	19.2 (17.1–21.5)	30.6 (27.8–33.7)
2007
Women age 40 and under	1141	40.2	11.2	48.6	40.6	12.1 (10.3–14.1)	39.8 (36.9–42.7)	53.1 (49.8–56.5)
Women age 41–45	1648	48.1	16.0	35.9	Not reached	7.3 (6.2–8.7)	26.5 (24.4–28.8)	41.8 (39.0–44.7)
2008
Women age 40 and under	1544	35.7	10.3	54.0	13.9	19.5 (17.7–21.6)	48.5 (46.0–51.1)	61.2 (58.2–64.2)
Women age 41–45	2167	42.4	15.4	42.2	67.7	11.4 (10.1–12.8)	35.4 (33.4–37.5)	48.4 (45.9–51.0)
2009
Women age 40 and under	1767	30.2	10.3	59.5	4.5	28.6 (26.6–30.8)	57.3 (54.9–59.7)	N/A
Women age 41–45	2571	37.9	16.0	46.2	42.1	17.2 (15.8–18.7)	43.1 (41.1–45.1)	N/A
2010
Women age 40 and under	1700	23.3	12.4	64.4	2.1	34.1 (31.9–36.4)	61.5 (59.2–63.9)	N/A
Women age 41–45	2158	28.0	19.1	52.8	15.0	22.7 (21.0–24.5)	48.4 (46.2–50.5)	N/A
2011
Women age 40 and under	1572	18.1	13.8	68.1	0.8	38.7 (36.3–41.1)	66.4 (64.0–68.7)	N/A
Women age 41–45	2234	22.7	18.8	58.6	4.5	29.7 (27.9–31.7)	56.1 (54.1–58.3)	N/A
2012
Women age 40 and under	1674	12.8	14.2	73.0	0.2	47.5 (45.1–49.9)	72.9 (70.7–75.1)	N/A
Women age 41–45	2309	15.2	20.0	64.8	1.0	38.3 (36.3–40.3)	65.3 (63.3–67.3)	N/A

^*The beginning of the Kaplan-Meier ascertainment period was defined as six months before the date of breast cancer surgery

^†95% CI=95% pointwise confidence interval for the Kaplan-Meier estimate