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. Author manuscript; available in PMC: 2017 Jul 21.
Published in final edited form as: Breast Cancer Res Treat. 2015 Dec 26;155(1):165–173. doi: 10.1007/s10549-015-3658-y

Table 2.

Rates of BRCA1/2 mutation testing

Year of breast surgery N Outcomes of Kaplan-Meier analysis (%) Kaplan-Meier estimates of BRCA1/2 testing rates*
Censored before 12/31/13 Follow up to 12/31/13 BRCA1/2 testing Median time to testing (Months after surgery) By surgery date % (95% CI) By one year after surgery % (95% CI) By five years after surgery % (95% CI)
2005
 Women age 40 and under 914 63.0 10.9 26.0 Not reached 4.9 (3.7–6.5) 19.6 (17.0–22.5) 35.3 (31.1–39.9)
 Women age 41–45 1375 63.6 15.9 20.5 Not reached 2.2 (1.5–3.1) 13.1 (11.4–15.2) 25.0 (22.1–28.2)
2006
 Women age 40 and under 888 45.3 11.6 43.1 66.4 6.6 (5.2–8.5) 32.9 (29.9–36.3) 48.3 (44.5–52.3)
 Women age 41–45 1323 54.7 17.6 27.7 Not reached 4.8 (3.7–6.1) 19.2 (17.1–21.5) 30.6 (27.8–33.7)
2007
 Women age 40 and under 1141 40.2 11.2 48.6 40.6 12.1 (10.3–14.1) 39.8 (36.9–42.7) 53.1 (49.8–56.5)
 Women age 41–45 1648 48.1 16.0 35.9 Not reached 7.3 (6.2–8.7) 26.5 (24.4–28.8) 41.8 (39.0–44.7)
2008
 Women age 40 and under 1544 35.7 10.3 54.0 13.9 19.5 (17.7–21.6) 48.5 (46.0–51.1) 61.2 (58.2–64.2)
 Women age 41–45 2167 42.4 15.4 42.2 67.7 11.4 (10.1–12.8) 35.4 (33.4–37.5) 48.4 (45.9–51.0)
2009
 Women age 40 and under 1767 30.2 10.3 59.5 4.5 28.6 (26.6–30.8) 57.3 (54.9–59.7) N/A
 Women age 41–45 2571 37.9 16.0 46.2 42.1 17.2 (15.8–18.7) 43.1 (41.1–45.1) N/A
2010
 Women age 40 and under 1700 23.3 12.4 64.4 2.1 34.1 (31.9–36.4) 61.5 (59.2–63.9) N/A
 Women age 41–45 2158 28.0 19.1 52.8 15.0 22.7 (21.0–24.5) 48.4 (46.2–50.5) N/A
2011
 Women age 40 and under 1572 18.1 13.8 68.1 0.8 38.7 (36.3–41.1) 66.4 (64.0–68.7) N/A
 Women age 41–45 2234 22.7 18.8 58.6 4.5 29.7 (27.9–31.7) 56.1 (54.1–58.3) N/A
2012
 Women age 40 and under 1674 12.8 14.2 73.0 0.2 47.5 (45.1–49.9) 72.9 (70.7–75.1) N/A
 Women age 41–45 2309 15.2 20.0 64.8 1.0 38.3 (36.3–40.3) 65.3 (63.3–67.3) N/A
*

The beginning of the Kaplan-Meier ascertainment period was defined as six months before the date of breast cancer surgery

95% CI=95% pointwise confidence interval for the Kaplan-Meier estimate