Table 3.

Multivariable Cox proportional hazards model for BRCA1/2 testing^*

	HR (95% CI)	P
Diagnosis year/cohort		<0.001
2005
Women age ≤ 40	Reference
Women age 41–45	0.71 (0.60–0.84)
2006
Women age ≤ 40	1.70 (1.44–2.00)
Women age 41–45	0.97 (0.82–1.14)
2007
Women age ≤ 40	2.11 (1.81–2.46)
Women age 41–45	1.39 (1.19–1.62)
2008
Women age ≤ 40	2.71 (2.34–3.13)
Women age 41–45	1.83 (1.59–2.12)
2009
Women age ≤ 40	3.42 (2.97–3.94)
Women age 41–45	2.23 (1.94–2.57)
2010
Women age ≤ 40	4.03 (3.50–4.65)
Women age 41–45	2.75 (2.39–3.17)
2011
Women age ≤ 40	4.77 (4.14–5.50)
Women age 41–45	3.48 (3.03–4.00)
2012
Women age ≤ 40	6.05 (5.26–6.97)
Women age 41–45	4.63 (4.03–5.33)
Insurance plan type†		<0.001
PPO	Reference
CDHP	1.14 (1.05–1.24)
Comprehensive	1.01 (0.87–1.17)
EPO	1.05 (0.93–1.19)
HDHP	1.26 (1.13–1.40)
HMO	0.86 (0.82–0.91)
POS	1.03 (0.97–1.10)
POS with capitation	1.17 (0.98–1.41)
Missing/unknown	0.90 (0.83–0.98)
Region		<0.001
South	Reference
Northeast	1.15 (1.09–1.21)
South Central	1.18 (1.13–1.23)
West	1.06 (1.00–1.11)
Missing/unknown	1.18 (1.06–1.32)

^*The outcome was the first BRCA1/2 testing claim recorded, using a Cox proportional hazards model that included the three independent variables listed in this table.

^†Insurance plan type: PPO, preferred provider organization; CDHP, consumer-driven health plan (PPO combined with a health reimbursement arrangement); EPO, exclusive provider organization (all care managed by a primary care physician with referrals required, payment non-capitated); HDHP (high deductible health plan combined with health savings account); HMO, health maintenance organization; POS, point-of-service (primary care physician manages care; patients incentivized to use particular providers).