Table 1.
Baseline characteristics of study subjects by treatment group (median (25th, 75th percentiles))
| Variable | Placebo | 1.25 g T | 2.5 g T | 5 g T | 10 g T | 15 g T | p-value |
|---|---|---|---|---|---|---|---|
| Number of subjects | 8 | 9 | 6 | 9 | 8 | 8 | |
| Age (years) | 45 (36,48) |
45 (41,46) |
43 (39,48) |
34 (30,44) |
42 (34,45) |
51 (48,53) |
0.15 |
| BMI (kg/m2) | 28 (26,31) |
28 (25,33) |
27 (24,28) |
25 (25,27) |
25 (23,28) |
27 (25,28) |
0.50 |
| Serum Hormones | |||||||
| Testosterone (nmol/L) | 15.6 (11.2,17.8) |
15.6 (12,17.7) |
16.9 (15.6,20.4) |
14.5 (13.4,17.5) |
16.7 (15.3,19.9) |
15 (13.1,18.6) |
0.71 |
| Dihydrotestosterone (nmol/L) | 1.2 (1,1.6) |
1.3 (0.8,1.5) |
1.4 (1.3,1.5) |
1.3 (0.6,1.7) |
1.7 (1.5,1.8) |
1.4 (1,2) |
0.35 |
| Estradiol (pmol/L) | 77.1 (60.5,104.8) |
82.9 (73.2,95.1) |
47.5 (46.4,76.6) |
84.8 (55.1,122.4) |
62.9 (54.5,71.3) |
79 (54,95) |
0.29 |
| Sex-hormone binding globulin (nmol/L) | 22.1 (16.4,34.5) |
20.1 (18.6,25.1) |
25 (22.4,42.3) |
20.6 (15.7,27.2) |
31.9 (30.1,33.6) |
30.5 (23.9,37.9) |
0.14 |
| Serum Lipids | |||||||
| Cholesterol (mmol/L) | 5.5 (5.2,6) |
4.9 (4.5,5.5) |
4.6 (4.2,5.7) |
5.1 (4.5,5.7) |
4.5 (4.2,5.1) |
4.7 (4.4,6.2) |
0.68 |
| Triglycerides (mmol/L) | 1.7 (1.4,2.3) |
1.5 (0.9,1.6) |
1.1 (0.9,1.2) |
1.0 (0.9,1.3) |
1.4 (1.2,1.9) |
1.6 (0.9,2.1) |
0.24 |
| LDL (mmol/L) | 3.4 (2.9,3.8) |
3.0 (2.5,3.4) |
2.6 (2.2,3) |
2.9 (2.4,3.6) |
2.6 (2.4,2.9) |
3.0 (2.7,3.6) |
0.50 |
| HDL (mmol/L) | 1.3 (1.1,1.4) |
1.3 (1.1,1.7) |
1.6 (1.5,1.7) |
1.6 (1.2,1.8) |
1.3 (1.1,1.6) |
1.2 (1,1.2) |
0.31 |
| Metabolic parameters | |||||||
| Glucose (mmol/L) | 5.2 (5.2,5.3) |
5.4 (4.9,5.6) |
5.7 (5.5,6) |
5.5 (5,5.6) |
5.2 (5.1,5.3) |
5.4 (5.1,5.6) |
0.25 |
| Insulin (pmol/L) | 51 (44,104) |
47 (31,71) |
57 (49,81) |
63 (47,81) |
49 (41,69) |
70 (56,87) |
0.73 |
| HOMA-IR | 11.8 (10,25.3) |
11.4 (6.5,17.8) |
14.7 (12.2,22.4) |
14 (12,20.1) |
10.8 (9.1,16.7) |
16.1 (12.5,21.4) |
0.71 |
| Adiponectin (mcg/mL) | 10.1 (5.7,17.2) |
8.9 (8,12) |
10.8 (7.9,14.1) |
7 (5.1,8.1) |
15.7 (11.6,19.8) |
7.3 (5.1,8.8) |
0.01* |
| Leptin (ng/mL) | 6.5 (4.5,13.7) |
9.5 (5.5,15) |
5.7 (3.3,10.6) |
5.7 (4.3,14.1) |
3.9 (2.5,6) |
4.7 (2.1,9.3) |
0.51 |
*
= p-value <0.05 on Kruskal-Wallis ANOVA
kg/m2 = kilograms per meter(squared). nmol/L = nanomoles per liter. pmol/L = picomoles per liter. mIU/mL = milli-international units per milliliter. mmol/L = millimoles per liter. mcg/mL = micrograms per milliliter. ng/mL = nanograms per milliliter.