Table 1.
Incidence of CTC, CTC apoptosis, and CTC clusters.
| A. Incidence of CTC | ||||||
|---|---|---|---|---|---|---|
| CTC/7.5ml WB | ≥5 CTC/7.5 ml WB By Randomized Arm | |||||
| ≥1 | ≥3 | ≥5 | nab-PAC | nab-PAC + TIG | p-value | |
| Baseline | 61.5% (32/52) | 50.0% (26/52) | 36.5% (19/52) | 31.6% (6119) | 39.4% (13/33) | 0.57 |
| Day 15 | 42 .3% (22/52) | 32.7% (17/52) | 26.9% (14/52) | 15.8 (3119) | 33 .3% (11/33) | 0.17 |
| Day 29 | 38.8% (19/49) | 28.6% (14/49) | 26.5% (13/49) | 22.2% (4118) | 290% (9/31) | 0.74 |
| B. Incidence of CTC-apoptosis and CTC-clusters | |||||
|---|---|---|---|---|---|
| CTC-Apoptosisa | CTC-Clustersb | ||||
| Baseline | Day 15 | Day 29 | Baseline | Day 15 | Day 29 |
| 5/19 (26.3%) | 7/14 (50.0%) | 8/13 (61.5%) | 8/32 (25.0%) | 4/22 (18.2%) | 7/19 (36.8%) |
| C. Apoptosis according to single vs. clustered CTC at any time during the trial | |||
|---|---|---|---|
| Single CTC | CTC-cluster | ||
| # of single CTC cells | % single cell positive for apoptosis | # of CTC in the cluster | % CTC cluster with 1 cell positive for apoptosis |
| 8393 | 20% | 943 | 0.4% |
| D. Apoptosis according to single vs. clustered CTC at baseline, day 15, and day 29 | |||
|---|---|---|---|
| Baseline | Day 15 | Day 29 | |
| Single cell | 516/2678 (19%) |
363/1505 (24%) |
795/4210 (19%) |
| Cluster | 1/16 1 (0.6%) |
0/283 (0%) |
3/499 (0.6%) |
a
Of those ≥ 5CTC/7.5 ml WB;
b
Of those with ≥ 1 CTC/7.5 1111 WE.