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. Author manuscript; available in PMC: 2017 Jul 21.
Published in final edited form as: Clin Cancer Res. 2015 Mar 16;21(12):2771–2779. doi: 10.1158/1078-0432.CCR-14-2781

Table 2.

Association of CTC enumeration, apoptosis, and clusters with outcomes.

Baseline
CTC-Enumerationa CTC-Apoptosisb CTC-Clustersc
ORR p CBR p PFS p ORR p CBR p PFS p ORR p CBR p PFS p
No 12/33
(36.4)		 0.25 23/33
(69.7)		 0.02 1 3.6 0.005 3/14
(21.4)		 1.0 6/14
(42.9)		 0.60 1.9 0.47 5/24
(20.8)		 1.0 11124
(45.8)		 1.0 2.3 0.34
Yes 4/19
(21.1)		 7/19
(36.8)		 1.9 1/5
(20.0)		 1/5
(20.0)		 2.1 1/8
(12.5)		 3/8
(37.5)		 2.0
Day 15
CTC-Enumerationa CTC-Apoptosisb CTC-Clustersc
ORR P CBR P PFS P ORR P CBR P PFS P ORR P CBR P PFS P
No 14/3 8
(36.8)		 0.34 26/38
(684)		 0.010 3.6 0.0003 2/7
(28.6)		 1.0 2/7
(28.6)		 1.0 1.8 0.11 5/18
(27 .8)		 0.54 7/18
(3 8.9)		 0.26 2.5 0.028
Yes 3/14
(21.4)		 4/14
(28.6)		 1.9 1/7
(14.3)		 2/7
(28.6)		 2.1 0/4
(0)		 0/4
(0)		 1.8
Day 29
CTC-Enumerationa CTC-Apoptosisb CTC-Clustersc
ORR P CBR P PFS P ORR P CBR P PFS P ORR P CBR P PFS P
No 14/36
(38.9)		 0.043 27/36
(75.0)		 0.0002 3.7 0.0002 0/5
(0)		 1.0 115
(20.0)		 1.0 1.8 0.73 4112
(33.3)		 0.25 6112
(50.0)		 0.04 4 2.7 0.009
Yes. 1/13
(7.7)		 2/13
(15.4)		 1.9 1/8
(12.5)		 1/8
(12.5)		 2.0 0/7
(0)		 0/7
(0)		 1.8
a

For CTC-enumeration No<5 CTC/7.5 ml, Yes≥5CTC/7.5 ml;

b

For CTC-Apoptosis No ≥5CTC/7.5 ml with <25% apoptic, Yes≥5CTC/7.5 ml with 2>25% apoptotic;

c

CTC-cluster No ≥1 CTC/7.5 ml with no cluster; Yes ≥1 CTC with at least 1 cluster; ORR = overall response rate, sum of complete response (CR) plus partial response (PR); CBR=clinical benefit rate stable disease (SD) plus PR, and CR; PFS=Progression free survival; p=p value. (Note values in parentheses are numbers expressed in %; PFS is median time to progression in months.