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. 2016 Nov 15;8(12):3703–3717. doi: 10.1093/gbe/evw276

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© The Author(s) 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

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Fig. 4.— — Heat maps representing significant association found when comparing Rodentia EBRs (left panel) and control genome-like regions (right panel) with epigenetic modifications in 58 different mouse cell lines based on 10,000 permutation test with randomization (P-value < 0.05). Red squares indicate positive association (enrichment with P-value < = 0.05); white squares indicate no statistical association (P-value > 0.05), whereas blue squares indicate depletion (P-value < = 0.05). Black squares reflect no data available. The x-axis represents: (1x) Skeletal system, (2x) Muscular system, (3x) Circulatory system, (4x) Nervous system, (5x) Respiratory system, (6x) Digestive system, (7x) Excretory system, (8x) Endocrine system, (9x) Reproductive system, (10x) Lymphatic system, (11x) Stem cells, and (12x) Other. The y-axis shows: (1y) Histone modifications leading to “close” chromatin, (2y) Histone modifications associated with “open” chromatin, (3y) DNase-seq, (4y) Transcription factors, (5y) Other.