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. Author manuscript; available in PMC: 2018 Aug 30.
Published in final edited form as: Gene. 2017 May 25;626:309–318. doi: 10.1016/j.gene.2017.05.048

Fig. 8. Schematic illustration of a proposed mechanism of alcohol-induced deregulation of Pol III genes.

Fig. 8

Ethanol induces activation of JNK1 to upregulate Brf1 expression, which in turn enhances Pol III gene transcription to promote alcohol-induced cell transformation.