Table 4. Accuracy of first trimester glycated haemoglobin and placental peptides as markers of gestational diabetes.

Threshold values	Sensitivity (95% CI)	Specificity (95% CI)	AUC (95% CI)	P-value
GDM
FBG 1(mmol/L) 3.75	33.3% (9.93–65.1)	72.0% (64.2–79.7)	0.49 (0.31–0.67)	0.928
FBG 2 (mmol/L) 5.6	100% (73.5–100)	95.7% (90.8–98.4)	0.99 (0.97–1.00)	<0.0001
HBA1c (%) 5.6	33.3% (9.93–65.1)	87.0% (80.2–92.1)	0.53 (0.33–0.72)	0.8004
Insulin (μIU/mL) 28.5	41.7% (15.2–72.3)	94.1% (88.7–97.4)	0.51 (0.28–70)	0.9244
B-HCG 4947	100% (73.5–100)	7.65 (3.0–12.0)	0.53 (0.37–0.70)	0.7084
P4 74.95	58.3% (27.7–84.8)	71.0%(62.7–78.4)	0.67 (0.54–0.79)	0.050
E2 5256	50.0% (21.1–78.9)	63.0% (54.4–71.1)	0.53 (0.38–0.68)	0.737
HPL 65.61	50% (21.1–78.9)	71.7 (63.5–79.1)	0.59 (0.39–0.79)	0.305

FBG;fasting blood glucose, HB; haemoglobin, HbA1c; glycated haemoglobin, SBP; systolic blood pressure, DBP; diastolic blood pressure, BMI; body mass index, TC; total cholesterol, TG; triglyceride, β-HCG; beta-human chorionic gonadotropin,IR:insulin resistant, P4; Progesterone, E2; Estradiol, HPL; Human Placenta Lactogen