Table 2.

Variants associated with lower 24-h EE, lower RMR, and higher maximum BMI in American Indians

Chr.	Position	Variant ID	Gene(s)	R/NR allele	RAF	24-h EE (n = 419)		RMR (n = 509)		Maximum BMI (n = 5,870)
						β (SE)	P	β (SE)	P	β (SE)	P
10	25735858	rs11014566	GPR158	G/A	0.60	−33.0 (10.5)	1.7 × 10−3	−31.1 (12.1)	9.9 × 10−3	0.017 (0.005)	4.7 × 10−4
21	30662480	—	LINC00189, BACH1	—/AAG	0.30	−30.6 (11.1)	6.0 × 10−3	−34.5 (13.3)	9.4 × 10−3	0.014 (0.005)	3.9 × 10−3
12	97806525	rs12424131	NEDD1, RMST	A/G	0.88	−42.8 (15.5)	5.6 × 10−3	−55.8 (19.2)	3.6 × 10−3	0.018 (0.007)	9.9 × 10−3
12	97810465	rs17026922	NEDD1, RMST	G/A	0.92	−46.8 (17.8)	8.5 × 10−3	−65.7 (22.6)	3.6 × 10−3	0.020 (0.008)	1.2 × 10−2
14	21113898	rs56069351	OR6S1, ANG	T/C	0.25	−33.0 (11.7)	4.9 × 10−3	−42.1 (14.1)	2.7 × 10−3	0.012 (0.005)	1.5 × 10−2
20	4157857	rs1538072	SMOX	G/C	0.77	−35.9 (12.7)	4.6 × 10−3	−52.1 (15.0)	5.4 × 10−4	0.012 (0.006)	3.4 × 10−2
3	77645020	rs80275771	ROBO2	A/T	0.16	−38.8 (14.8)	8.9 × 10−3	−45.9 (16.9)	6.7 × 10−3	0.014 (0.007)	3.9 × 10−2

Variant position is based on human genome Build 37. Variant identification number (rs no.) is based on dbSNP version 141. Risk (R) allele is defined as the allele associated with lower 24-h EE, lower RMR, and higher maximum BMI. RAF was calculated in full-heritage Pima Indians. β-Coefficient (β) is expressed per copy of the risk allele in kcal/day (24-h EE and RMR) and log_e (BMI) units. Results are adjusted for age, sex, FM and FFM (only for 24-h EE and RMR analyses), SPA (only for 24-h EE), birth year (only for BMI analysis), and the first five genetic principal components in a mixed model that accounted for genetic relationships among individuals. Variants are sorted by their P value for the association with maximum BMI. Chr., chromosome; NR, nonrisk.