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Angiotensin-(1–7) promotes insulin secretion only in islets expressing neprilysin. Insulin secretion in response to 2.8 or 20 mmol/L glucose and insulin content from C57BL/6.NEP+/+ (A and B; n = 8–9) and C57BL/6.NEP−/− (C and D; n = 6) islets after a 48-h culture in the absence or presence of 1 nmol/L angiotensin-(1–7). Data are the mean ± SEM. *P < 0.05 vs. vehicle.
