Figure 5.

Liraglutide increases cardiac efficiency. A: The slope of the relationship between cardiac power and PVA was greater in liraglutide-treated swine hearts. The increased ratio of PVA (an index of cardiac oxygen consumption) to cardiac power evident in liraglutide-treated animals establishes that liraglutide increased the ratio of cardiac work to cardiac energetics. P value is by ANCOVA; P = 0.02 for homogeneity of regressions. B: To better establish efficiency at each dose of dobutamine, the ratio of cardiac power to the PVA was calculated for each animal at each dose. Liraglutide therapy increased the efficiency of this relationship overall (P = 0.005) and at the highest dose of dobutamine relative to both baseline and the dobutamine dose-matched saline control. *P < 0.05 comparing individual doses against baseline within the treatment group. †P < 0.05 comparing the treatment groups under resting conditions. Saline (n = 5) and liraglutide (n = 7).