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. 2017 Jun 13;40(8):1082–1089. doi: 10.2337/dc17-0290

Table 1.

Clinical features of the study population according to the TCF7L2 rs7903146 genotype

Caucasians
African Americans
Hispanics
CC CT TT P value CC CT TT P value CC CT TT P value
N 174 187 42 140 107 24 141 119 21
Age (years) 14.2 ± 3.9 13.6 ± 3.3 13.2 ± 2.9 0.118 13.3 ± 3.4 13.3 ± 3.2 14.3 ± 4.3 0.367 12.3 ± 3.1 13.1 ± 3.1 11.8 ± 3.1 0.186
Sex (male/female), % 32/68 44/55 43/57 0.041 42/58 38/62 38/62 0.800 48/52 39/61 62/38 0.085
BMI z score 2.0 ± 0.81 2.2 ± 0.58 2.1 ± 0.64 0.055 2.3 ± 0.51 2.2 ± 0.71 2.1 ± 0.55 0.297 2.1 ± 0.76 2.2 ± 0.65 1.9 ± 1.4 0.374
Tanner 1/2–3/4–5, % 7/25/68 5/37/58 12/26/62 0.061 13/36/51 7/43/50 4/33/63 0.308 11/45/44 8/38/54 14/48/38 0.429
Fasting glucose (mg/dL) 90.2 ± 8.3 91.2 ± 8.3 93.9 ± 10.3 0.036 91.5 ± 8.6 92.1 ± 8.6 93.3 ± 7.1 0.466 91.6 ± 7.7 92.7 ± 8.6 96.6 ± 12.0 0.082
2-h glucose (mg/dL) 118.4 ± 26.3 123.2 ± 27.4 137.1 ± 34.9 0.006 117.7 ± 28.5 129.5 ± 31.5 122.0 ± 26.4 0.009 117.8 ± 20.7 124.3 ± 24.4 129.0 ± 31.0 0.072
HbA1c (%) 5.4 ± 0.30 5.4 ± 0.30 5.5 ± 0.34 0.057 5.5 ± 0.35 5.6 ± 0.37 5.7 ± 0.45 0.094 5.5 ± 0.27 5.5 ± 0.36 5.5 ± 0.37 0.990
HbA1c (mmol/mol) 36 ± 2.3 36 ± 2.3 37 ± 2.39 0.057 37 ± 2.4 38 ± 2.4 39 ± 2.9 0.094 37 ± 1.98 37 ± 2.3 37 ± 2.4 0.990
Insulin (μU/mL) 30.3 ± 17.2 34.2 ± 19.7 33.2 ± 15.8 0.225 34.5 ± 18.2 37.4 ± 29.4 34.4 ± 13.7 0.320 30.3 ± 17.2 35.7 ± 18.0 42.7 ± 32.0 0.038
WBISI (I2/mg/μU) 2.1 ± 1.3 1.9 ± 1.1 1.8 ± 1.2 0.267 1.8 ± 1.2 2.0 ± 1.6 1.6 ± 0.61 0.322 2.0 ± 1.1 1.6 ± 0.94 2.1 ± 1.7 0.062
IGI (μU/mg) 4.2 ± 4.0 4.2 ± 3.3 3.8 ± 3.4 0.769 6.2 ± 4.8 6.6 ± 9.7 6.4 ± 5.0 0.072 4.6 ± 3.8 4.6 ± 3.0 3.7 ± 3.5 0.266
DI (I2/mg2) 6.9 ± 6.8 6.0 ± 4.3 5.5 ± 3.0 0.090 9.2 ± 5.7 7.9 ± 7.8 8.6 ± 6.0 0.010 7.6 ± 5.9 6.6 ± 4.7 6.0 ± 5.9 0.051
OMM
 N 138 127 25 89 71 16 110 73 15
 Φb (10−9 min−1) 14.7 ± 6.3 14.9 ± 6.1 13.3 ± 7.2 0.490 13.8 ± 5.5 12.6 ± 6.7 12.2 ± 5.5 0.347 13.7 ± 4.5 15.7 ± 6.5 12.1 ± 6.0 0.839
 Φd (10−9 min−1) 1,395.9 ± 765.6 1,431.5 ± 929.7 1,386.7 ± 996.2 0.880 1,963.7 ± 1,064.0 1,788.8 ± 1,270.1 1,431.6 ± 926.5 0.127 1,649.0 ± 1,007.9 1,679.4 ± 907.9 1,209.2 ± 525.6 0.626
 Φs (10−9 min−1) 81.6 ± 49.8 76.4 ± 43.0 52.2 ± 23.0 0.010 87.4 ± 63.2 62.0 ± 36.3 75.1 ± 33.2 0.039 85.7 ± 62.7 78.2 ± 34.3 50.8 ± 19.8 0.858
 Φtotal (10−9 min−1) 96.4 ± 55.0 97.1 ± 54.7 64.2 ± 27.8 0.003 111.347 ± 66.2 80.2 ± 40.8 88.1 ± 44.0 0.002 106.8 ± 70.9 92.8 ± 42.5 66.8 ± 26.2 0.035
 SI (10−5 dL · kg −1 · min−1/pmol · L−1) 26.1 ± 23.4 25.0 ± 20.2 30.6 ± 27.7 0.841 24.9 ± 18.4 26.9 ± 21.8 20.4 ± 15.1 0.742 27.1 ± 18.5 17.0 ± 12.1 24.3 ± 15.0 0.003

Data are mean ± SD unless otherwise indicated.

IGI, insulinogenic index; WBISI, whole-body insulin sensitivity index.