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Dom34 facilitates the release of 80S ribosomes from a subset of 3′UTRs. Ribosome footprints indicative of assembled 80S ribosomes are seen in a subset of 3′UTR regions in dom34Δ mutant cells. Unlike 80S ribosome footprints from ORFs, however, these do not show periodicity and represent ribosomes that have failed to properly release following translation termination.
