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. 2017 Mar 30;8(26):41947–41962. doi: 10.18632/oncotarget.16710

Figure 4. PLOD2 regulates the expression of EMT-associated genes in glioma cells through PI3K/AKT signaling pathways.

Figure 4

(A) Knockdown of endogenous PLOD2 in U251 and U87 cells reduced the expression of several EMT-marker genes including Snail, Slug, Vimentin and N-cadherin but enhanced E-cadherin expression. (B) Reduced PLOD2 expression significantly decreased the expression of phosphorylated PI3K, AKT, GSK3β and β-catenin, whereas total levels remained unchanged. β-actin was used as a loading control.