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. 2017 Jan 31;8(26):42030–42042. doi: 10.18632/oncotarget.14925

Figure 7. Excitability analysis of iPSC derived mature MNs by electrophysiology in voltage-clamp mode.

Figure 7

A. Sodium currents (INa) were reliably elicited from a holding potential of -70 mV by 10 mV increments to +30 mV in 400 ms duration in SMA III (red, 1), SMA I (green, 3) and control (blue, 2) groups. B. Current voltage relations for the Na+ current density evoked between −70 mV and +30 mV in all three groups. C. Summary of the maximal Na+ current density for each group (one-way ANOVA, *P < 0.05). n=18 neurons for each individual. All data shown represent mean ± SEM.