Table 1. HPV16 expression in peripheral blood and fresh tumor tissue samples of HNSCC in Southwest China and its association with clinicopathologic characteristics.
Variable | HPV (PB) | P-value | HPV (TS) | P-value | ||
---|---|---|---|---|---|---|
Negative | Positive | Negative | Positive | |||
Age | 0.0101 | 0.0170 | ||||
<60 | 60 | 29 | 60 | 25 | ||
≥60 | 89 | 18 | 81 | 14 | ||
Gender | 0.897 | 0.804 | ||||
Mae | 84 | 27 | 80 | 23 | ||
Female | 65 | 20 | 61 | 16 | ||
Smoking status | <0.001 | 0.0106 | ||||
Current/former | 86 | 10 | 74 | 11 | ||
Never | 63 | 37 | 67 | 28 | ||
Alcohol use | 0.0002 | |||||
Positive | 79 | 7 | <0.001 | 77 | 8 | |
Negative | 70 | 40 | 64 | 31 | ||
Clinical Stage | 0.422 | 0.978 | ||||
I+II | 63 | 23 | 69 | 19 | ||
III+IV | 86 | 24 | 72 | 20 | ||
Tumor Localization | 0.001 | 0.001 | ||||
Mouth Floor | 25 | 6 | 21 | 4 | ||
Tongue | 69 | 17 | 61 | 15 | ||
Oropharyngeal | 9 | 13 | 7 | 10 | ||
Buccal Mucosa | 46 | 11 | 52 | 10 | ||
Pathological Stage | 0.005 | 0.034 | ||||
High | 46 | 7 | 49 | 10 | ||
Middle Grade | 63 | 10 | 51 | 9 | ||
Low Grade | 40 | 30 | 41 | 20 |
Chi-square was reported to compare the difference between HPV status and clinical-pathological characteristics. Former/current smokers defined as >= one pack-year history of smoking. Positive alcohol use was defined as current alcohol use of >one drink per day for 1 year (12 oz of beer with 5% alcohol, 5 oz of wine with 12% to 15% alcohol, or 1 oz of liquor with 45% to 60% alcohol).