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. 2017 Feb 2;8(26):42214–42225. doi: 10.18632/oncotarget.15031

Figure 5.

Figure 5

A. Weighted gene co-expression network analysis of the whole transcriptome data. B. A cluster of clusters analysis presented connected expression modules. Expression module 1 and 2 were contained in one cluster. C. Detailed cluster branches of expression module 1 and 2 were illustrated. Corresponding correlation heatmaps of PD-L1 expression and module-contained genes are given in the panel below the branches. Scatterplots of intramodule connectivity (KME) confirmed the strong correlation of PD-L1 expression and the expression modules. D. Gene Set Enrichment Analysis of expression module 1 identified INFγ related genes (upper panel) and immune response (bottom panel). E. Created network analysis of expression module 1/2 based on intramodule connectivity, derived from WGCNA. Size and colours indicate the intensity of intramodule connectivity.