A. The change rate of Tg per month in individual patients before and after apatinib therapy. The change rate of Tg per month was calculated according to the following formula: (Tg–Tgbaseline)/ Tgbaseline/ month. B. The change in sum of target lesion diameter per month in individual patients before and after apatinib therapy. The change in sum of target lesion diameter per month (ΔTTD per month) was calculated according to the following formula: (TTD–TTDbaseline)/month. C. The change in SUVmax of target lesions after apatinib therapy. The change in SUVmax was defined as ΔSUVmax, which was calculated according to the following formula: SUVmax–SUVmaxbaseline. D. The change rate of Tg, SUVmax, TTD in individual patient after 8 weeks of apatinib therapy. The change rate of Tg was calculated according to the following formula: (Tg–Tgbaseline)/ Tgbaseline. The change rate of SUVmax was calculated according to the following formula: (SUVmax–SUVmaxbaseline)/SUVmaxbaseline. The change rate of TTD was calculated according to the following formula: (TTD–TTDbaseline)/TTDbaseline. Tg, thyroglobulin; TTD, total tumor diameter which was defined as sum of the diameter of target lesions; SUVmax, maximum standard uptake value.