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. 2017 Mar 15;8(26):42343–42358. doi: 10.18632/oncotarget.16216

Figure 3. Single agent efficacy of G1T38 in breast cancer.

Figure 3

(A) Mice received 100 mg/kg of G1T38 or vehicle in their diet for 28 days. Food pellets were prepared with the expectation that 100 mg/kg of G1T38 would be orally ingested per day under the parameters that 25 gm mice eat 3.2 gm per day; these parameters were based on previous experience. After 21 days, tumor progression was calculated using the formula: (21 day volume – initial volume)/ initial volume x 100. (B) G1T38 or palbociclib efficacy after 28 days of oral treatment (100 mg/kg, 50 mg/kg, 10 mg/kg) in MCF7 xenograft model. Yellow bar represents duration of treatment. Statistics were completed using linear regression analysis of time during treatment (28 days). Error bars represent SEM. **p≤0.01.