Table 1. In vitro biochemical activity of G1T38.

	CDK4/Cyclin D1	CDK6/Cyclin D3	CDK9/Cyclin T	CDK5/p35	CDK5/p25	CDK2/Cyclin A	CDK1/Cyclin B1	CDK7/Cyclin H/ Mat1	CDK2/Cyclin E
Mean (μM)	.001	.002	.028	0.832	1.2	1.5	2.4	2.4	3.6

Biochemical profiling of G1T38 in Nanosyn, Inc. (Santa Clara, CA) kinase screen for CDKs. The assays were completed using microfluidic kinase detection technology (Caliper Assay Platform). The compounds were tested in 12-point dose response format in singlicate at Km for ATP. Results are displayed as micromolar concentrations for IC₅₀ curves against putative target.