Table 2. Growth inhibitory effects of G1T38 on CDK4/6-dependent and CDK4/6-independent cell lines.

Cell Line	Tumor Type	RB Status	G1T38 EC50 (nM)
MV4-11	B cell leukemia	+	23
MCF7	ER+ breast cancer	+	52
SupT1	Lymphoma	+	57
ZR-75-1	ER+ breast cancer	+	61
WM2664	Melanoma	+	125
Tom1	Ph1+ leukemia	+	232
BV173	Ph1+ leukemia	+	296
Daudi	Lymphoma	+	784
A2058	Melanoma	-	2691
H69	SCLC	-	2915
NALM1	Leukemia	-	>10000

EC₅₀ concentrations (nM) of G1T38 and RB status of tumorigenic cell lines.