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. 2017 Mar 21;8(26):42398–42413. doi: 10.18632/oncotarget.16392

Figure 2. ERG-related status influences the incidence of genomic microdeletions and their association with prognosis.

Figure 2

(A) Event free survival (EFS) of ERG-related and non-ERG-related B-others patients analyzed by MLPA (95) according to the presence of IKZF1 aberrations. Events occurred later than 5 years from diagnosis are also indicated in the figure but are not included in the EFS curve (e.g. IK+ERG+ annotated event occurred 6.9 years from diagnosis). IK+: presence of IKZF1 aberrations (intragenic or whole gene); IK-: absence of IKZF1 aberrations; ERG+: ERG-related; ERG-: non-ERG-related. (B) Histogram representing the incidence of IKZF1 aberrations isolated or co-occurring with the other genomic microdeletions included in the SALSA MLPA P335-B1 ALL-IKZF1 assay in ERG-related patients with or without ERG intragenic deletion and in non-ERG-related B-other patients (95). IKZF1 Del plus: IKZF1 aberrations (intragenic or whole gene deletions) and one or more aberrations of B-cell differentiation genes; IKZF1 Del only: IKZF1 aberrations in the absence of aberrations of B-cell differentiation genes; IKZF1 wt plus: lack of IKZF1 aberrations but aberrations of B-cell differentiation genes ; No aberrations of B-cell differentiation genes including IKZF1.