Skip to main content
. 2017 Apr 18;8(26):42466–42477. doi: 10.18632/oncotarget.17198

Figure 2. Pharmacological interactions between pemetrexed, cisplatin, and cSBL in H28 cells.

Figure 2

(A) The drug concentration ratios were as follows: pemetrexed + cisplatin (1:2), pemetrexed + cSBL (20:1), cisplatin + cSBL (40:1). Cells were treated with pemetrexed (2 nM–400 μM), cisplatin (4 nM–800 μM), or cSBL (0.1 nM–20 μM) for 72 h. The horizontal axis indicates the concentration of pemetrexed in the pemetrexed + cisplatin or pemetrexed + cSBL combination or the concentration of cisplatin in the cisplatin + cSBL combination. (B) CI-Fa curves for H28 cells treated with pemetrexed + cisplatin, pemetrexed + cSBL, or cisplatin + cSBL. CI values < 1 indicate a synergistic effect, and CI values > 1 indicate an antagonistic effect. Each data point represents the mean ± SD of three independent WST-8 assays. Each sample was plated in triplicate.