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. 2017 Apr 18;8(26):42510–42524. doi: 10.18632/oncotarget.17207

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Copyright: © 2017 Wang et al.

This article is distributed under the terms of the Creative Commons Attribution License (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.

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Graphical Abstract: Discovery of Eg5 inhibitor YL001 as a novel antitumor agent — Left, two rounds of virtual screening results in the discovery of YL001 as an Eg5 inhibitor which can lead to monopolar spindle phenotype. Right, YL001 exhibits potent antitumor activity in the B16 xenograft mouse model.