Table 1. Top differentially expressed genes (FDR<0.001 and log2ratio≥5) and miRNAs.
| Symbol | Gene Name | Log2Ratio | P-value | FDR (q-value) |
|---|---|---|---|---|
| Upregulated | ||||
| CDX1 | caudal type homeobox 1 | 8.166 | 2.28×10−5 | 7.83×10−4 |
| SI | sucrase-isomaltase (alpha-glucosidase) | 7.111 | 2.42×10−8 | 8.73×10−6 |
| KRT16 | keratin 16 | 6.917 | 9.18×10−13 | 7.94×10−9 |
| SERPINB5 | serpin peptidase inhibitor, clade B (ovalbumin), member 5 | 6.561 | 2.80×10−14 | 4.85×10−10 |
| TINAG | tubulointerstitial nephritis antigen | 6.286 | 5.46×10−8 | 1.43×10−5 |
| CST1 | cystatin SN | 6.250 | 2.27×10−8 | 8.36×10−6 |
| PITX1 | paired-like homeodomain 1 | 6.081 | 2.78×10−8 | 9.47×10−6 |
| HOXA10 | homeobox A10 | 6.054 | 2.70×10−12 | 1.28×10−8 |
| LINC00460 | long intergenic non-protein coding RNA 460 | 5.987 | 7.85×10−8 | 1.76×10−5 |
| UGT1A9 | UDP glucuronosyltransferase 1 family, polypeptide A8 | 5.978 | 1.23×10−10 | 1.78×10−7 |
| SLCO1B7 | solute carrier organic anion transporter family, member 1B7 | 5.772 | 9.51×10−7 | 9.84×10−5 |
| HOTTIP | HOXA distal transcript antisense RNA | 5.707 | 3.37×10−6 | 2.19×10−4 |
| SLC6A14 | solute carrier family 6 (amino acid transporter), member 14 | 5.586 | 2.96×10−12 | 1.28×10−8 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 5.582 | 9.32×10−9 | 4.61×10−6 |
| MSLN | mesothelin | 5.187 | 5.31×10−7 | 6.81×10−5 |
| TMPRSS4 | transmembrane protease, serine 4 | 5.118 | 1.80×10−11 | 6.23×10−8 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | 5.031 | 1.47×10−7 | 2.62×10−5 |
| Downregulated* | ||||
| SYCN | syncollin | −8.059 | 1.70×10−6 | 1.44×10−4 |
| PLA2G1B | phospholipase A2, group IB (pancreas) | −7.822 | 2.01×10−5 | 7.17×10−4 |
| GP2 | glycoprotein 2 (zymogen granule membrane) | −7.728 | 1.63×10−5 | 6.14×10−4 |
| RBPJL | recombination signal binding protein for immunoglobulin kappa J region-like | −6.646 | 8.63×10−7 | 9.24×10−5 |
| SERPINI2 | serpin peptidase inhibitor, clade I (pancpin), member 2 | −6.620 | 3.63×10−7 | 5.18×10−5 |
| PRSS3 | protease, serine, 3 | −6.240 | 5.50×10−6 | 3.05×10−4 |
| KLK1 | kallikrein 1 | −6.224 | 2.31×10−6 | 1.74×10−4 |
| ERP27 | endoplasmic reticulum protein 27 | −6.103 | 1.51×10−6 | 1.34×10−4 |
| PDIA2 | protein disulfide isomerase family A, member 2 | −6.044 | 6.12×10−7 | 7.51×10−5 |
| AQP8(Ins) | aquaporin 8 | −5.982 | 4.63×10−6 | 2.76×10−4 |
| CLPSL1 | colipase-like 1 | −5.977 | 5.12×10−9 | 2.95×10−6 |
| GPHA2 | glycoprotein hormone alpha 2 | −5.868 | 2.58×10−6 | 1.86×10−4 |
| GUCA1C | guanylate cyclase activator 1C | −5.841 | 5.92×10−7 | 7.42×10−5 |
| GSTA2 | glutathione S-transferase alpha 2 | −5.827 | 2.73×10−6 | 1.91×10−4 |
| TMEM52 | transmembrane protein 52 | −5.711 | 1.38×10−5 | 5.52×10−4 |
| PNLIPRP2 | pancreatic lipase-related protein 2 | −5.596 | 2.95×10−5 | 9.39×10−4 |
| ATP4A | ATPase, H+/K+ exchanging, alpha polypeptide | −5.319 | 1.82×10−9 | 1.44×10−6 |
| PM20D1 | peptidase M20 domain containing 1 | −5.251 | 2.34×10−6 | 1.74×10−4 |
| C12orf39 | chromosome 12 open reading frame 39 | −5.045 | 4.83×10−8 | 1.33×10−5 |
| CCKBR(Ins) | cholecystokinin B receptor | −5.041 | 5.81×10−8 | 1.44×10−5 |
| MiRNA | ||||
| miR-614 | 3.64 | 3.36×10−7 | 4.92×10−5 | |
| miR-217 | −4.21 | 2.64×10−6 | 1.87×10−4 | |
| miR-27b | −2.15 | 3.10×10−4 | 0.0048 | |
| miR-4451 | −1.74 | 1.09×10−3 | 0.012 | |
| miR-3609 | −1.15 | 1.57×10−3 | 0.015 | |
| miR-612 | 0.91 | 4.81×10−3 | 0.034 |
* Sixteen downregulated genes that are coding for pancreatic digestive enzymes are not listed. The complete list of the downregulated genes are presented in Supplementary Table 3.